Endocrine Abstracts

Objectives: Type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS) are characterized by insulin resistance and often associated with male hypogonadism. To discriminate the specific contribution of T2DM and MetS to male hypogonadism.Design and methods: A consecutive series of 1134 (mean age 52.1±13 years) male patients with sexual dysfunction was studied. Several hormonal and biochemical parameters were studied along with ANDROTEST, a 12-item ...

Aspergillus infection (A)is often recognized in severely immunocompromised patients.Although involvement of the thyroid gland is reported for 9–15% of patients with disseminated disease, a localized clinical picture it’s not reported.Here, we present a case of Aspergillus in a LES young patient (15-year-old girl), who underwent to a strong immunosuppressive regimen (high doses of corticosteroids, endoxan and...

A strong evidence suggests the role of BRAFV600E mutation in determining the aggressiveness of thyroid cancer. To detect how the association of BRAF mutation could influence the aggressiveness of particular subtypes of thyroid tumors, we analysed a possible correlation between BRAFV600E and metalloproteinase (MMPs) activity, as its enhanced production could be an important determinant of tumor invasion. For this purpose, we investigated the activity and t...

Adult GHD patients may have reduced BMD, which is thought to be reverted by long-term rhGH replacement therapy. We have recently reported high prevalence of vertebral osteoporotic deformities in untreated adult GHD patients. Gonadal status is the main determinant of bone loss in patients with primary form of osteoporosis.In this cross-sectional study, we investigated whether the prevalence and degree of spinal deformities in adults with treated or untrea...

Objectives: The aim of present study was to verify possible differences in the prevalence of vasculogenic ED and hypogonadism comparing two distinct new definitions of MetS, as National Cholesterol Education Program-Third Adult Treatment Panel (NCEP-ATPIII) and International diabetes Federation (IDF) in patients with sexual dysfunction.Methods: Several hormonal, biochemical and instrumental (penile doppler ultrasound) parameters were studied. ANDROTEST S...

In a previous study we demonstrated that retinoic acid (RA) decreased the growth only of thyroid carcinoma cell lines expressing RA receptor β (RAR β) and that decitabine (5-Aza-CdR) re-induced RARβ expression. The aim of this study was to analyze the effects induced by the combined treatment with RA and 5-Aza-CdR in the same thyroid cancer cell lines.We studied the effect of 5-Aza-CdR 800 nM and RA 1 μM on the expression of thyroid s...

Background: Primary empty sella (ES) can be asymptomatic or associated with endocrine and neurological alterations, such as visual defects. Studies in a large number of patients is still lacking.Objective: To study visual deficit in ES and its relationship with hormonal status.Material and Methods: We recorded visual evoked potentials (VEP) by white/black, red/black, blue/black patterns. Isoluminance between red and blue checks all...

Objectives: Detecting hypogonadism is crucial in patients with sexual dysfunctions because hypogonadism can have a causal role for them and testosterone (T) substitution represents a milestone for the therapy. At present, three different inventories have been developed for screening of hypogonadism in aging male. All these instruments demonstrated a good sensitivity but low specificity. No inventories are available for the screening of hypogonadism in patients with sexual dysf...

Introduction: Anger is an emotional state of feelings varying from mild irritation to intense rage, whereas aggression implies externalizing angry emotions through destructive/ punitive behavior towards other persons/objects. Although research on the relationship between testosterone and aggression is inconclusive, the WPATH SOC 7 guidelines have warned for an increase in aggression in transgender men (TM) taking testosterone treatment.Aims:<p class=...

Introduction: Clinical and laboratory hyperandrogenisms indistinctly contribute to PCOS diagnosis; however, they differ in hormonal and metabolic correlates and require proper therapeutic strategies. Circulating biomarkers of hirsutism were not identified so far, with elevated testosterone being observed only in half of hirsute patients. Reasons for such inconsistencies possibly relies in previously used immunoassays, nowadays recognized as not adequate because of poor reliabi...